Thermo Fisher Scientific LIMK2 Polyclonal Antibody
LIMK2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC에 사용 가능하며, actin cytos켈레톤 조절 연구에 적합합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal part of human LIMK2 (LIM domain kinase 2, LIMK-2) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity: LIMK2.
Target Information
LIMK2 is a serine/threonine kinase involved in the regulation of actin cytoskeletal changes via phosphorylation of cofilin. It has been implicated in brain development.
Although zinc fingers typically bind DNA or RNA, the LIM motif mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 form a subfamily characterized by two N-terminal LIM motifs and a C-terminal kinase domain.
LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and subsequently phosphorylates cofilin, inhibiting its actin-depolymerizing activity. This pathway contributes to Rho-induced reorganization of the actin cytoskeleton.
At least three transcript variants encoding different isoforms of LIMK2 have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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