Thermo Fisher Scientific LATS2 Polyclonal Antibody
LATS2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에서 사용 가능하며, 인간 및 마우스 반응성. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장.
- 카탈로그번호
- OSL00007W-100UL
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 5–50 of mouse LATS2 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: LATS2
Target Information
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. It interacts with a negative regulator of p53 and functions in a positive feedback loop with p53 that responds to cytoskeleton damage, provoking centrosome and mitotic apparatus dysfunction.
LATS2 is essential for maintaining mitotic fidelity and genomic integrity. It plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
This pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1, which then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, regulating genes responsible for cell proliferation, death, and migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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