Thermo Fisher Scientific LATS2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous PubMed (Misc)

• Publications: View 4 publications

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: LATS2

Target Information

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. It interacts with a negative regulator of p53 and functions in a positive feedback loop with p53 that responds to cytoskeleton damage, provoking centrosome and mitotic apparatus dysfunction.
LATS2 is essential for maintaining mitotic fidelity and genomic integrity. It plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
This pathway involves a kinase cascade where STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1, which then phosphorylates and inactivates YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS2 inhibits its nuclear translocation, regulating genes responsible for cell proliferation, death, and migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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