Thermo Fisher Scientific LATS1 Polyclonal Antibody
LATS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC에 사용 가능. Mouse와 Rat에 반응하며, 동결건조 형태로 제공. 세포주기 조절 단백질 연구 및 종양 억제 기전 연구에 적합.
- 카탈로그번호
- OSL00008W-100UL
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LATS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 4 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide to the C-terminal of mouse LATS1 (WARTS) conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4 °C for short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: LATS1.
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell-cycle dependent manner. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through intramolecular binding. LATS1 acts as a tumor suppressor and plays an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors, and sensitivity to carcinogenic treatments.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.