Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR/4929R)
Thermo Fisher Scientific의 재조합 토끼 단클론 항체로 인간 Androgen Receptor를 특이적으로 인식. IHC(Paraffin)에서 1–2 µg/mL 농도로 사용 가능. 핵 내 단백질 검출에 적합하며, 남성 생식기 및 전립선 관련 연구에 활용. 연구용으로만 사용.
- 카탈로그번호
- 367-RBM9-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR/4929R)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | DHTR/4929R |
| Immunogen | Recombinant human AR protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Breast LNCap cells, human testis, prostate, or prostate carcinoma
- Cellular Location: Nucleus
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor (>90 kDa) with three major functional domains:
- N-terminal domain
- DNA-binding domain
- Androgen-binding domain
Upon binding testosterone (T) or dihydrotestosterone (DHT), AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway is essential for development and function of male reproductive organs (prostate, epididymis) and also active in nonreproductive tissues (muscle, hair follicles, brain).
AR is a phosphoprotein that regulates MAP kinase signaling. Inhibition of MEK1/2 affects AR phosphorylation.
Abnormal AR signaling is associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.