Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Recombinant Rabbit Monoclonal Antibody (DHTR/4929R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Breast LNCap cells, human testis, prostate, or prostate carcinoma
• Cellular Location: Nucleus

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors.
It is a ligand-activated transcription factor (>90 kDa) with three major functional domains:

1. N-terminal domain
2. DNA-binding domain
3. Androgen-binding domain

Upon binding testosterone (T) or dihydrotestosterone (DHT), AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

The AR signaling pathway is essential for development and function of male reproductive organs (prostate, epididymis) and also active in nonreproductive tissues (muscle, hair follicles, brain).
AR is a phosphoprotein that regulates MAP kinase signaling. Inhibition of MEK1/2 affects AR phosphorylation.
Abnormal AR signaling is associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.