Thermo Fisher Scientific B7-H3 Monoclonal Antibody (06)
인간 B7-H3/CD276 단백질을 인식하는 Mouse IgG2b 단클론 항체로, ICC/IF, Flow Cytometry, ELISA에 사용 가능. 보존제 무첨가 액상 형태이며, Protein A로 정제됨. 연구용으로 면역반응 및 암 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 |
| Flow Cytometry (Flow) | 1:25–1:100 |
| ELISA | 1:1,000–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 06 |
| Immunogen | Recombinant Human B7-H3/CD276 protein (Met1–Thr461) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.12 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785030 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to prevent contamination (final concentration 0.05%–0.1%).
This antibody specifically recognizes Human B7-H3/CD276.
Target Information
CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that promotes proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and stimulates interferon gamma production.
Expression can be induced on dendritic cells and monocytes by inflammatory cytokines, and it is widely expressed in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms due to gene duplication and differential splicing.
CD276 has therapeutic potential in regulating cell-mediated immune responses to cancer, particularly when combined with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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