Thermo Fisher Scientific DEDD2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DEDD2, validated for WB, IHC(P), and IP. Recognizes amino acids 175–193 of DEDD2. Suitable for apoptosis-related research. Supplied as liquid whole serum with sodium azide, stored at 4°C or -20°C.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC(P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 175–193 of human DEDD2/Flame-3 (GenBank no. gi 19923050, ref NP_579874.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718759 |
Target Information
Apoptotic signals are often triggered by cell surface death receptors through protein–protein interactions mediated by conserved domains such as the death effector domain (DED).
DEDD2 is a novel DED-containing protein identified to play a role in apoptosis regulation. Overexpression of DEDD2 induces moderate apoptosis and sensitizes cells to Fas, TRAIL, and FADD-induced apoptosis.
DEDD2 binds caspase-8 and -10, as well as FLIP, but not FADD. It translocates from the cytosol to the nucleus upon apoptosis induction, suggesting a role in targeting caspase-8 to the nucleus and mediating death receptor-induced apoptosis.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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