Thermo Fisher Scientific PTPN13 Polyclonal Antibody
Human PTPN13 단백질을 표적하는 Rabbit Polyclonal Antibody로 Western blot, IHC, IP에 적합. 비결합형 액상 형태이며 4°C 또는 -20°C에서 보관. 세포 성장 및 신호 조절 연구에 활용 가능.
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Thermo Fisher Scientific PTPN13 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 | - |
| Immunoprecipitation (IP) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1760–1775 of human FAP-1 (GenBank no. NP_542414.1). Conserved across multiple FAP-1 isoforms. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718761 |
Target Information
PTPN13 is a member of the protein tyrosine phosphatase (PTP) family, acting as a signaling molecule that regulates cell growth, differentiation, mitosis, and oncogenic transformation. It is a large intracellular protein with a catalytic PTP domain at the C-terminus, five PDZ domains, and a FERM domain that associates with plasma membrane and cytoskeletal structures. PTPN13 interacts with and dephosphorylates Fas receptor and IkappaBalpha, suggesting a role in Fas-mediated apoptosis. It also interacts with GTPase-activating proteins, potentially regulating Rho signaling pathways. Four alternatively spliced transcript variants are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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