Thermo Fisher Scientific DEDD2 Polyclonal Antibody
DEDD2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot, IHC, IP 등 다양한 응용 가능. 인간, 개, 소, 원숭이, 쥐 등에서 반응하며, 세포 사멸 경로 연구에 적합. 연구용으로만 사용.
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Thermo Fisher Scientific DEDD2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 210–228 of human DEDD2/Flame-3 (GenBank no. gi 19923050, ref NP_579874.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at –20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2718758 |
Target Information
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain.
DEDD2 is a novel DED-containing protein that induces moderate apoptosis and sensitizes cells to apoptosis induced by Fas, TRAIL, and FADD.
It binds caspase-8 and -10, and FLIP, but not FADD. DEDD2 translocates from cytosol to nucleus upon apoptosis induction, possibly targeting caspase-8 to the nucleus, playing a critical role in death receptor-induced apoptosis.
Two alternatively spliced transcript variants encoding distinct isoforms have been identified for DEDD2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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