Thermo Fisher Scientific Dectin-1 Polyclonal Antibody
Dectin-1(CLEC7A) 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 ELISA에 적합하며, 세포막 및 세포질에 위치한 단백질 검출에 활용됩니다. Affinity chromatography로 정제된 고순도 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 140–240 of human CLEC7A (NP_922938.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2809086 |
Product Specific Information
Immunogen sequence:
SWDGSKRQCW QLGSNLLKID SSNELGFIVK QVSSQPDNSF WIGLSRPQTE VPWLWEDGST FSSNLFQIRT TATQENPSPN CVWIHVSVIY DQLCSVPSYS I
Positive Samples:
H-460, SGC-7901, HL-60, Mouse spleen, Mouse thymus, Mouse liver, Mouse lung, Rat spleen
Cellular Location:
Cell membrane, Cytoplasm, Single-pass type II membrane protein
Target Information
CLEC7A (also known as Dectin-1) is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic ITAM motif. CLEC7A functions as a pattern-recognition receptor that recognizes beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, playing a key role in innate immune responses. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, inducing an oxidative burst through reactive oxygen species formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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