Thermo Fisher Scientific KIR2DL4 Monoclonal Antibody (mAb#33)
인간 KIR2DL4 단백질을 인식하는 마우스 단클론 항체로, ICC/IF, Flow Cytometry, IP 등에 사용 가능. 비결합(Unconjugated) 형태이며 Protein A로 정제됨. 4°C 보관, 동결 금지. 연구용으로만 사용 가능.
- 카탈로그번호
- MA110110
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 2–6 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | mAb#33 |
| Immunogen | NK3.3 cells and KIR2DL4-Ig fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157893 |
Available Conjugated Formats
Product Specific Information
This antibody recognizes the extracellular portion of CD158d / KIR2DL4, a 45 kDa NK cell marker. Cell surface expression and function of CD158d / KIR2DL4 depend on the genotype of individual donors.
Target Information
CD158d / KIR2DL4 is a member of the KIR family that shares structural features with both activating and inhibitory receptors, mediating different functions depending on context. It contains a cytoplasmic ITIM motif suggesting inhibitory function, but also a transmembrane domain similar to activating KIRs.
CD158d serves as an inhibitory receptor for peripheral and uterine NK cells; however, ligation with soluble mAbs can activate IFN-gamma secretion. It binds both membrane-bound and soluble forms of its ligand HLA-G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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