Thermo Fisher Scientific DAP3 Monoclonal Antibody (42C617.1.2)

Applications

Western Blot (WB)

• Tested Dilution: 3–5 µg/mL
• View 1 publication

Miscellaneous PubMed (Misc)

• Tested Dilution: —
• View 1 publication

Product Specifications

Product Specific Information

• This sequence is 75% homologous in mouse and rat.
• Suggested positive control: Jurkat, antigen standard for DAP3 (transient overexpression lysate), Jurkat whole cell lysate.

Target Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist in protein synthesis within the mitochondrion. Mitoribosomes consist of a small 28S subunit and a large 39S subunit, with an estimated 75% protein to rRNA ratio—opposite to prokaryotic ribosomes. Unlike prokaryotic ribosomes, mammalian mitoribosomes lack a 5S rRNA.
The proteins comprising the mitoribosome differ across species in sequence and biochemical properties, complicating recognition by sequence homology.
This gene encodes a 28S subunit protein involved in apoptotic pathways triggered by TNF-α, Fas ligand, and interferon-γ. It may bind ATP/GTP and interact with mitoribosomal protein S27. Splice variants differing in the 5′ UTR encode the same protein. Pseudogenes are located on chromosomes 1q and 2q.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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