Thermo Fisher Scientific CHK2 Monoclonal Antibody (73C175.1.1)
CHK2 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC, Flow 등 다양한 응용에 사용 가능. 인간 및 마우스 반응성, Protein G 정제, 액상 형태로 제공. DNA 손상 반응 및 암 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | 2–5 µg/mL |
| Flow Cytometry (Flow) | 1–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 73C175.1.1 |
| Immunogen | A portion of amino acids 100–150 of human Chk2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1073616 |
Product Specific Information
Suggested positive control: antigen standard for CHEK2 (transient overexpression lysate), human spleen.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase and a component of the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers. CHK2 is activated by DNA damage and phosphorylates modulators of cell cycle control, including tumor suppressor proteins. It can phosphorylate BRCA1, aiding survival after DNA damage. Chk2 acts as a putative tumor suppressor, with mutations associated with Li-Fraumeni syndrome and predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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