Thermo Fisher Scientific PPAR delta Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-823A detects peroxisome proliferator activated receptor (PPAR) delta from rat, human, and mouse cells.
This antibody does not detect PPAR alpha or PPAR gamma.
It has been successfully used in Western blot, immunohistochemistry, and immunofluorescence procedures.
By Western blot, it detects an ~49 kDa protein representing PPAR delta from NIH-3T3 cell lysate, showing predominant nuclear staining.

The immunogen is a synthetic peptide corresponding to residues M(1) E Q P Q E E T P E A R E E(14) C of mouse PPAR delta, with 86% sequence conservation in human PPAR delta.
PA1-823A immunizing peptide (Cat. # PEP-026) is available for neutralization and control experiments.

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family, which are nuclear hormone receptors that regulate peroxisome production and mediate various biological processes.
PPAR delta may play roles in diabetes, obesity, atherosclerosis, and cancer development.
It acts as an inhibitor of ligand-induced transcriptional activity of PPAR alpha and PPAR gamma, and may integrate transcription repression with nuclear receptor signaling.
Expression is elevated in colorectal cancer cells and regulated by APC tumor suppressor protein.
Knockout studies in mice suggest involvement in myelination, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.