Thermo Fisher Scientific RXRB Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-815 detects retinoid X receptor (RXR) beta from human and mouse cells, as well as transfected human and mouse RXR beta.
It has been successfully used in Western blot, immunoprecipitation, and gel shift procedures.
By Western blot, this antibody detects an approximately 50 kDa protein representing RXR beta from COS cells transfected with the human gene.
Gel shift assays reveal supershifting of vitamin D receptor (VDR)/RXR beta/vitamin D receptor response element (VDRE) complexes when PA1-815 is preincubated with RXR beta prior to addition of VDR.

The PA1-815 immunogen is a synthetic peptide corresponding to residues Q(190) K S D Q G V E G P G A T(202) of mouse RXR beta.

Recombinant human VDR (Cat. # RP-710) and human RXR beta (Cat. # RP-812) proteins can be purchased separately for control experiments in Western blot, immunoprecipitation, and gel shift procedures.

Target Information

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors that mediate the effects of retinoic acid (RA).
The receptor forms homodimers with retinoic acid, thyroid hormone, and vitamin D receptors, enhancing DNA binding and transcriptional function on their respective response elements.
The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.