Thermo Fisher Scientific RORA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-812 detects human ROR alpha protein in transfected cell samples and is specific for alpha isotypes.
It has been successfully used in Western blot procedures. By Western blot, this antibody detects an approximately 56 kDa protein representing ROR alpha in transfected BL21 cells using a pGEX-hROR alpha1-GST vector.
The immunogen is a synthetic peptide corresponding to residues K(541) E L F T S E F E P A M Q I D G(556) of human ROR alpha. This peptide (Cat. # PEP-230) is available for use in neutralization and control experiments.

Target Information

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain.
RORA binds either as a monomer or as a homodimer to the retinoic acid response element and regulates gene expression and cell function.
Although the exact function of RORA is not fully understood, it interacts with NM23-2, NM23-1, CDK7, NCOA3, and NCOA6 coactivators.
It is expressed in mesenchymal stem cells derived from bone marrow and modulates bone matrix components.
RORA is widely expressed in most tissues, and chromosomal aberrations involving RORA may be associated with acute promyelocytic leukemia (APL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.