Thermo Fisher Scientific DR3 Polyclonal Antibody
Western blot 및 ICC/IF에 적합한 DR3 폴리클로날 항체입니다. Human 및 Mouse 시료에 반응하며, Rabbit IgG로 생성되었습니다. 세포자멸사 및 림프구 항상성 연구에 유용합니다. 액상 형태로 제공되며, 냉장 또는 냉동 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids in extracellular domain of human DR3 precursor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152259 |
Product Specific Information
In Western blot applications, this antibody detects a band at approximately 59 kDa.
A suggested positive control is Jurkat cell lysate.
Target Information
DR3 (TNFRSF25) is a member of the TNF-receptor superfamily, expressed mainly in lymphocyte-rich tissues.
It plays a role in regulating lymphocyte homeostasis and can stimulate NF-kappa B activity and control apoptosis.
Signal transduction occurs via death domain-containing adaptor proteins.
Mouse knockout studies indicate its role in eliminating self-reactive T cells in the thymus.
Multiple alternatively spliced transcript variants exist, producing distinct isoforms, many of which are secreted.
Upon T-cell activation, full-length membrane-bound isoforms are predominantly expressed, contributing to lymphocyte proliferation control.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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