Thermo Fisher Scientific MADD Polyclonal Antibody
MADD 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, Human, Mouse, Rat에서 반응. 고순도 이온교환 크로마토그래피로 정제된 액상 항체로, 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific MADD Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids near the carboxy terminus of human MADD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153446 |
Product Specific Information
- In Western blot applications, this antibody detects a band at approximately 200–220 kDa.
- Suggested positive control: HeLa cell lysate.
- PA5-19879 can be used with blocking peptide PEP-0012.
Target Information
Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF.
MADD (Mitogen Activated Protein (MAP)-kinase Activating Death Domain Protein) associates with the death domain of TNFR1 through its own C-terminal death domain, which is critical for TNFR1 signal generation.
Overexpression of MADD activates MAP kinases ERK and JNK and induces phosphorylation of cytosolic phospholipase A2. This suggests that MADD links TNF signaling with MAP kinase activation and arachidonic acid release.
MADD shows 98% homology with DENN (Differentially Expressed in Neoplasmic vs. Normal cells) and 93% sequence conservation with a GDP/GTP exchange protein, Rab3.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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