Thermo Fisher Scientific HAP1 Polyclonal Antibody
HAP1 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체. 인간, 마우스, 랫트에서 반응하며 WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, 2-8°C에서 단기 보관 및 -20°C 장기 보관 가능.
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Thermo Fisher Scientific HAP1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the center of human HAP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154836 |
Product Specific Information
- Suggested positive control: mouse brain tissue lysate
- PA5-20377 can be used with blocking peptide PEP-0494
Target Information
Huntington's disease (HD) is a neurodegenerative disorder characterized by loss of striatal neurons, caused by expansion of a polyglutamine tract in the huntingtin protein. HAP1 was identified via two-hybrid screening; its binding to huntingtin correlates with polyglutamine tract expansion.
HAP1 interacts with cytoskeletal proteins dynactin and pericentriolar autoantigen protein 1, suggesting roles in vesicular trafficking or organelle transport. It also participates in huntingtin-enhanced BDNF transport along microtubules. Disruption of this process leads to reduced neurotrophic support and neuronal toxicity, potentially contributing to disease pathogenesis. Several alternatively spliced isoforms of HAP1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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