Thermo Fisher Scientific TSLP Receptor Polyclonal Antibody
Human TSLP 수용체를 인식하는 Rabbit Polyclonal 항체로, WB와 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.02% sodium azide를 포함합니다. 단백질 발현 분석 및 면역조직화학 연구용으로 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | - |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide from near the center of human TSLP receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157846 |
Product Specific Information
Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is human liver tissue lysate.
PA5-20378 can be used with blocking peptide PEP-0495.
Target Information
Thymic stromal lymphopoietin (TSLP) has been identified as a key factor that drives dendritic cell maturation and activation.
It plays roles in:
- Positive selection of regulatory T cells
- Maintenance of peripheral CD4+ T cell homeostasis
- Induction of CD4+ T cell-mediated allergic reactions
TSLP also supports the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development.
Its receptor, TSLP-R, binds TSLP with low affinity in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and formation of a functional heteromeric complex.
This receptor complex requires STAT5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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