Thermo Fisher Scientific TSLP Receptor Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.
A suggested positive control is human liver tissue lysate.
PA5-20378 can be used with blocking peptide PEP-0495.

Target Information

Thymic stromal lymphopoietin (TSLP) has been identified as a key factor that drives dendritic cell maturation and activation.
It plays roles in:

• Positive selection of regulatory T cells
• Maintenance of peripheral CD4+ T cell homeostasis
• Induction of CD4+ T cell-mediated allergic reactions

TSLP also supports the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development.
Its receptor, TSLP-R, binds TSLP with low affinity in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and formation of a functional heteromeric complex.
This receptor complex requires STAT5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.