Thermo Fisher Scientific Presenilin 1 Polyclonal Antibody
Thermo Fisher Scientific의 Presenilin 1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하는 rabbit IgG 형 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, Alzheimer 연구에 적합합니다. 액상 형태로 1 mg/mL 농도, 냉장 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 23 amino acid peptide from near the carboxy terminus of human presenilin1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152496 |
Product Specific Information
- Suggested positive control: human brain tissue lysate
- PA5-20376 can be used with blocking peptide PEP-0493
Target Information
Presenilin 1 is a marker of susceptibility to early-onset Alzheimer’s disease. Together with PEN2, nicastrin, and APH-1, Presenilin 1 forms the γ-secretase protein complex—a membrane-bound aspartyl protease that cleaves certain proteins within the lipid bilayer. This cleavage is crucial for signaling from various cell-surface receptors and is implicated in generating neurotoxic amyloid peptides central to Alzheimer’s disease pathogenesis. γ-secretase cleaves amyloid precursor protein (APP) within its intramembrane region, producing either non-toxic p3 or toxic Abeta amyloid peptides. Accumulation of Abeta peptide is considered a precursor to Alzheimer’s disease. Multiple isoforms of Presenilin 1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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