Thermo Fisher Scientific CD123 Polyclonal Antibody
Human IL-3 Receptor alpha(CD123)에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(Paraffin) 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 고농축 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human IL3 Receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792293 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: THP-1, IL3 Receptor alpha-transfected (+) 293T whole cell extracts.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and forms a heterodimer with a unique alpha chain paired with the common beta (βc or CDw131) subunit.
IL-3Ra mediates the signal transmission of Interleukin-3.
Heterodimerization of IL-3Ra and IL-3Rb chains is induced by Interleukin-3, which is required for receptor activation but not for high-affinity binding.
IL-3Ra subunits are reported to be overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells, making them potential targets for novel therapeutic agents.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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