Thermo Fisher Scientific MEK2 Polyclonal Antibody
MEK2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB에 최적화되어 있습니다. MEK1 및 기타 MAP kinase kinases와 교차 반응하지 않으며, 연구용으로만 사용됩니다. 고순도 항원 친화 크로마토그래피로 정제된 액상 항체입니다.
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Thermo Fisher Scientific MEK2 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human MEK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987148 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with MEK1 and other MAP kinase kinases.
Target Information
MAP2K2 (MEK2) is a dual specificity serine/threonine kinase that plays a critical role in mitogen growth factor signal transduction. MEK2 (MAPKK2) activates ERK1/2 and MAPK enzymes by phosphorylating residues within the TEY motif of the activation loop.
MEK1 and MEK2 are activated by dual phosphorylation on serine 218 and 222 within the activation loop. Threonine 292 of MEK1 is phosphorylated by ERK2, providing a negative feedback loop that suppresses MEK1 activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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