Thermo Fisher Scientific Phospho-Cyclin B1 (Ser147) Polyclonal Antibody
Cyclin B1의 인산화 형태(Ser147)를 검출하는 rabbit polyclonal antibody로, Western blot에 적합. 인간, 마우스, 돼지, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태이며, -20°C 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer147 of human cyclin B1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987459 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Cyclins bind to and regulate the activity of Cyclin dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and essential for cell cycle control at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts exist: one constitutively expressed and another predominantly during G2/M phase. Cyclin B1 accumulates during G2 phase and is destroyed at the end of mitosis via APC-dependent ubiquitination. Overexpression of Cyclin B1 is observed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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