Thermo Fisher Scientific Phospho-beta Catenin (Ser45) Polyclonal Antibody
인간 베타카테닌의 Ser45 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 보존제 무첨가, -20°C 보관. 세포 성장 및 부착 관련 신호전달 연구에 활용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-beta Catenin (Ser45) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer45 of human β-catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 75 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11002189 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to anchor adhesion complexes to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless, tyrosine kinases, and phosphatases.
The protein is expressed in various hair follicle cell types and epithelial tissues. Aberrant beta-catenin activity is implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating genes like cyclin D and c-myc that promote cell proliferation, linking it to tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.