Thermo Fisher Scientific Phospho-p130Cas (Tyr249) Polyclonal Antibody
인간, 마우스, 랫트에 반응하는 Rabbit IgG 폴리클로날 항체로 Tyr249 부위의 p130Cas 인산화 형태를 검출. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 액상 형태로 -20°C에 보관.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr249 of human p130Cas |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979463 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins.
p130Cas has a unique structure containing a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.
It is implicated in various biological processes such as:
- Cell adhesion and migration
- Growth factor stimulation
- Cytokine receptor engagement
- Bacterial infection
Physiological functions of p130Cas include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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