Thermo Fisher Scientific Phospho-IRS1 (Ser639) Polyclonal Antibody
인간, 생쥐, 랫트의 IRS-1 단백질 Ser639 인산화 부위를 인식하는 폴리클로날 항체. Western blot 및 IHC에 사용 가능하며, 고순도(>95%) 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, 장기 보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific Phospho-IRS1 (Ser639) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Serine 639 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553763 |
Product Specific Information
- Detects endogenous IRS-1 protein at molecular weights of 132 and 180 kDa.
- Purity >95% by SDS-PAGE.
Target Information
IRS-1 is a major substrate of the insulin receptor and is phosphorylated in response to stimulation by insulin, IGF-1, and IL-4. It undergoes phosphorylation on serine, threonine, and tyrosine residues across various tissues.
Casein kinase II mediates a portion of insulin-stimulated phosphorylation of IRS-1. Thr502 and Ser99 are major phosphorylation sites catalyzed by casein kinase II.
IRS-1 also contains three putative 14-3-3 binding sites (Ser270, Ser374, Ser641), with the Ser270 motif located in the phosphotyrosine binding domain responsible for interaction with the insulin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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