Thermo Fisher Scientific NMDAR2B Monoclonal Antibody (S59), FITC
FITC 형광 표지된 NMDAR2B 단일클론 항체(S59)로 인간, 마우스, 랫트 시료에 반응. WB, IHC, ICC/IF에 최적화. 단백질 G 정제, 보존제 없음. 신경세포 발달 및 기억 관련 연구에 적합.
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Thermo Fisher Scientific NMDAR2B Monoclonal Antibody (S59), FITC
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S59 |
| Immunogen | Fusion protein amino acids 20–271 (extracellular N-terminus) of rat NR2B |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.09 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931917 |
Additional Formats
- APC (Cat. No. MA5-45462)
- PerCP (Cat. No. MA5-45464)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45463 was sufficient for detection of NR2B in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 166 kDa. No cross-reactivity against NR2A.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, a process underlying synaptic plasticity, memory, and learning. NMDAR2B plays roles in neuronal development and is implicated in neurological disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death. Overexpression of NR2B is associated with enhanced learning and memory, while reduced expression correlates with cognitive decline. Tyr1472 phosphorylation on NR2B may increase NMDAR expression at synapses. NMDAR2B dysfunction is linked to epileptic encephalopathy and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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