Thermo Fisher Scientific NMDAR2B Monoclonal Antibody (S59), APC
NMDAR2B 단백질을 인식하는 S59 클론의 단일클론 항체로, APC로 결합되어 세포 분석에 적합합니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능하며, 인간, 마우스, 랫트 반응성을 보입니다. 단백질 G 정제, 보존제 없음, 4°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S59 |
| Immunogen | Fusion protein amino acids 20–271 (extracellular N-terminus) of rat NR2B |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931916 |
Available Formats
- FITC (Cat. MA5-45463)
- PerCP (Cat. MA5-45464)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45462 was sufficient for detection of NR2B in 10 µg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 166 kDa. No cross-reactivity against NR2A.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency, which is important for memory and learning.
They play a role in neuronal development and are implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of NR2B has been associated with enhanced learning and memory, whereas reduced expression is observed in aged, memory-impaired animals.
Phosphorylation of Tyr1472 on NR2B may increase synaptic NMDAR expression, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction is linked to epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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