Thermo Fisher Scientific Human Noggin Recombinant Protein, PeproTech
인간 유래 Noggin 재조합 단백질로, HEK293 세포에서 발현된 고순도(≥95%) 단백질입니다. BMP 억제 활성을 가지며 다양한 세포 분화 및 발달 연구에 활용됩니다. 동결건조 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: Not specified
- Publications: View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: Not specified
- Publications: View 1 publication
Functional Assay (Functional)
- Assay-dependent
- Publications: View 1 publication
Inhibition Assays (IA)
- Tested Dilution: Not specified
- Publications: View 1 publication
In vitro Assay (IV)
- Tested Dilution: Not specified
- Publications: View 140 publications
Miscellaneous PubMed (Misc)
- Tested Dilution: Not specified
- Publications: View 33 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Bovine, Chicken, Dog, Human, Mouse, Pig, Rat |
| Expression System | HEK293 cells |
| Amino Acid Sequence | QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC |
| Molecular Weight | 46 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Inhibits 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. Expected ED50: 2.0–3.0 ng/ml |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
Product Specific Information
- Catalog No. 120-10C-1MG is supplied as 2 × 500 µg (Cat. No. 120-10C-500UG).
- Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid chains.
- Monomeric glycosylated Noggin migrates at approximately 28–33 kDa by SDS-PAGE under reducing conditions.
- Shipped at ambient temperature. Refer to lot-specific Certificate of Analysis for storage, handling, and reconstitution details.
Target Information
Noggin participates in multiple developmental processes, including neural tube fusion and joint formation. It functions as a bone morphogenetic protein (BMP) inhibitor and plays a key role in organ morphogenesis via WNT3A-mediated β-catenin stabilization.
Mutations in the Noggin gene are associated with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1), conditions characterized by joint fusion abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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