Thermo Fisher Scientific Human Noggin Recombinant Protein, PeproTech

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• Publications: View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: Not specified
• Publications: View 1 publication

Functional Assay (Functional)

• Assay-dependent
• Publications: View 1 publication

Inhibition Assays (IA)

• Tested Dilution: Not specified
• Publications: View 1 publication

In vitro Assay (IV)

• Tested Dilution: Not specified
• Publications: View 140 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: Not specified
• Publications: View 33 publications

Product Specifications

Product Specific Information

• Catalog No. 120-10C-1MG is supplied as 2 × 500 µg (Cat. No. 120-10C-500UG).
• Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid chains.
• Monomeric glycosylated Noggin migrates at approximately 28–33 kDa by SDS-PAGE under reducing conditions.
• Shipped at ambient temperature. Refer to lot-specific Certificate of Analysis for storage, handling, and reconstitution details.

Target Information

Noggin participates in multiple developmental processes, including neural tube fusion and joint formation. It functions as a bone morphogenetic protein (BMP) inhibitor and plays a key role in organ morphogenesis via WNT3A-mediated β-catenin stabilization.
Mutations in the Noggin gene are associated with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1), conditions characterized by joint fusion abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.