Thermo Fisher Scientific Phospho-FGFR1 (Tyr766) Polyclonal Antibody
FGFR1 Tyr766 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 적합하며, 인간·마우스·랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGFR1 (Accession P11362), corresponding to amino acid residues around phosphorylated Tyr766 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816261 |
Product Specific Information
This antibody detects endogenous levels of FGFR1 only when phosphorylated at Tyrosine 766.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), a group of membrane-spanning tyrosine kinases that serve as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family is involved in mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic and adult stages.
Mutations or aberrations in FGFR1 are linked to various disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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