Thermo Fisher Scientific Phospho-FGFR1 (Tyr654) Polyclonal Antibody
FGFR1 인산화 Tyr654 잔기를 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 인간, 마우스, 영장류, 랫트 반응성. 고순도 액상 형태, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGFR1 (Accession P11362), corresponding to amino acid residues around phosphorylated Tyr654 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816262 |
Product Specific Information
Antibody detects endogenous levels of FGFR1 only when phosphorylated at Tyrosine 654.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which serve as high-affinity receptors for 17 growth factors (FGF1–17).
These receptors play crucial roles in mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms expressed differently during embryogenesis and adulthood.
Mutations or aberrations in FGFR1 are linked to several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal abnormalities involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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