Thermo Fisher Scientific SCNN1B Monoclonal Antibody (16E4), APC
SCNN1B 단백질을 인식하는 마우스 단클론 항체로, APC로 결합되어 형광 분석에 적합합니다. Western blot에 1:1,000 희석으로 사용 가능하며, 뇌, 신장 등에서의 ENaC β 단백질 검출에 유용합니다. 단백질 G로 정제된 액상 형태로 4°C에서 보관합니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16E4 |
| Immunogen | Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617–638) |
| Conjugate | APC (Allophycocyanin) |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931809 |
Additional Formats
- FITC: MA5-45356
- PerCP: MA5-45357
- Request custom conjugation
Product Specific Information
A 1:1,000 dilution of MA5-45355 was sufficient for detection of ENaC beta in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 87 kDa.
Target Information
Sodium-permeable, non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and also plays a role in taste perception.
The channel is a heterotetramer of two alpha, one beta, and one gamma subunit (a delta subunit can replace alpha). Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B cause:
- Autosomal recessive pseudohypoaldosteronism type 1 (PHA1) — a rare salt-wasting disease due to mineralocorticoid unresponsiveness.
- Liddle syndrome — an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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