Thermo Fisher Scientific SCNN1B Monoclonal Antibody (16E4), APC

Applications and Tested Dilution

• Western Blot (WB): 1:1,000

Product Specifications

Additional Formats

• FITC: MA5-45356
• PerCP: MA5-45357
• Request custom conjugation

Product Specific Information

A 1:1,000 dilution of MA5-45355 was sufficient for detection of ENaC beta in 15 µg of Mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 87 kDa.

Target Information

Sodium-permeable, non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and also plays a role in taste perception.

The channel is a heterotetramer of two alpha, one beta, and one gamma subunit (a delta subunit can replace alpha). Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B cause:

• Autosomal recessive pseudohypoaldosteronism type 1 (PHA1) — a rare salt-wasting disease due to mineralocorticoid unresponsiveness.
• Liddle syndrome — an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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