Thermo Fisher Scientific SCNN1B Monoclonal Antibody (16E4), PerCP
SCNN1B 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(16E4), PerCP 컨쥬게이트 제품. Western blot에 적합하며, 마우스 시료에서 87kDa 단백질 검출 가능. Protein G 정제, 보존제 무첨가, 4°C 보관.
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16E4 |
| Immunogen | Synthetic peptide from the C-terminal of Rat ENaC beta (aa. 617–638) |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931811 |
Additional Formats
Product Specific Information
A 1:1,000 dilution of MA5-45357 was sufficient for detection of ENaC beta in 15 µg of mouse whole kidney lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 87 kDa.
Target Information
Sodium-permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and plays a role in taste perception.
Forms a heterotetramer of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B are associated with autosomal recessive pseudohypoaldosteronism type 1 (PHA1) and Liddle syndrome, characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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