Thermo Fisher Scientific c-Met Recombinant Rabbit Monoclonal Antibody (001)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Mouse c-Met/Met/HGFR.

Target Information

MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC.

Biological roles:

• Embryonic development (gastrulation, muscle and neuron formation, angiogenesis, kidney development)
• Adult functions (wound healing, organ regeneration, tissue remodeling)

MET has been associated with cancers including gastric, renal, and breast cancers, making it a target for cancer therapeutics and diagnostics.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.