Thermo Fisher Scientific CD53 Recombinant Rabbit Monoclonal Antibody (013)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire

This antibody has specificity for Mouse CD53.

Target Information

CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. It forms complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4, or tetraspanins CD37, CD81, and CD82, modulating various signaling processes.

CD53 is involved in tumor cell radioresistance and has anti-apoptotic effects upon triggering. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, while neutrophil stimulation results in down-regulation of CD53 expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.