Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine Hydroxylase에 특이적인 Sheep Polyclonal Antibody로, WB·IHC·ICC 등 다양한 응용 가능. Rat, Human, Mouse 등 반응성 보유. 액상 형태로 -20°C 보관. 카테콜아민 신경전달물질 합성 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | 1:1,000 | View 7 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:1,000 | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Human, Many, Mouse |
| Published Species | Dog, Human, Mouse, Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| RRID | AB_561880 |
Product Specific Information
This antibody is specific for the ~60 kDa Tyrosine Hydroxylase in Western blots of rat brain extracts.
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity.
Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1–hTH4) have been isolated. These variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. TH is responsible for the conversion of L-tyrosine to L-dopa and plays a key role in the physiology of adrenergic neurons.
The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and several neuropathogenic diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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