Thermo Fisher Scientific TRPC5 Polyclonal Antibody
Rabbit polyclonal antibody against human TRPC5 protein. Validated for WB and IHC. Lyophilized form, reconstitutable in sterile water. Suitable for calcium channel research and TRPC family protein studies.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human TRPC5 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TRPC5.
Target Information
TRPC5 belongs to the transient receptor potential (TRP) family and is one of seven mammalian TRPC proteins. It is a multi-pass membrane protein forming receptor-activated, non-selective calcium-permeant cation channels. TRPC5 functions alone or as a heteromultimer with TRPC1, TRPC3, and TRPC4. It interacts with calmodulin, CABP1, enkurin, NHERF, MX1, RNF24, and SESTD1. TRPC5 is likely operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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