Thermo Fisher Scientific TRPC5 Polyclonal Antibody
TRPC5 단백질을 인식하는 양(IgG) 유래 polyclonal antibody로, Western blot 및 IHC에 적합합니다. 인간 TRPC5의 4번째 세포질 도메인 합성 펩타이드를 면역원으로 사용했습니다. 비결합형 동결건조 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 4th cytoplasmic domain of human TRPC5 (TRP5) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11007645 |
Product Specific Information
Reconstitute with 500 µL of distilled water.
Target Information
TRPC5 belongs to the transient receptor family and is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein that forms a receptor-activated non-selective calcium-permeant cation channel. It functions alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4.
TRPC5 interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). It is thought to be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective and may be activated by intracellular calcium store depletion.
Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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