Thermo Fisher Scientific TRPC5 Polyclonal Antibody
TRPC5 단백질을 인식하는 Sheep 유래 Polyclonal Antibody로, WB 및 IHC에 사용 가능. 인간 시료 반응성이 확인됨. Lyophilized 형태로 제공되며 PBS buffer에 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from 4th cytoplasmic domain of human TRPC5 (TRP5) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPC5.
Target Information
TRPC5 belongs to the transient receptor family and is one of seven mammalian TRPC (transient receptor potential channel) proteins.
The TRPC5 protein is a multi-pass membrane protein forming a receptor-activated non-selective calcium permeant cation channel.
TRPC5 functions alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4.
It interacts with multiple proteins including calmodulin, CABP1, enkurin, NHERF, MX1, RNF24, and SESTD1.
TRPC5 is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
It may also be activated by intracellular calcium store depletion.
Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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