Thermo Fisher Scientific MUC4 Recombinant Rabbit Monoclonal Antibody (HL1486)
MUC4 단백질을 검출하기 위한 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot 및 면역조직화학(IHC)에 적합하며, 인간과 생쥐 시료에 반응합니다. 고순도 Protein A 정제, 액상 형태, 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1486 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Mucin 4 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2938134 |
Product Specific Information
- Store as concentrated solution.
- Centrifuge briefly prior to opening vial.
Target Information
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts.
Mucin 4 (MUC4) is membrane-bound and plays an important role in protection and lubrication.
MUC4 expression is aberrant in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma.
Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers.
MUC4 is notably associated with certain Asian diseases such as Taiwanese infertility, endometriosis, and gallstone formation in Chinese men, where similar diseases in other populations do not share these MUC4 mutations.
Because MUC4 is critical for mucosal surface protection, its dysfunction has been implicated in many metastatic cancer invasions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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