Thermo Fisher Scientific Calnexin Recombinant Rabbit Monoclonal Antibody (HL1598)
Calnexin 단백질을 인식하는 재조합 토끼 단클론 항체로 Western blot 및 IHC(P) 분석에 적합. HEK293 세포에서 발현되며 Protein A로 정제된 고순도 항체. 다양한 종(Dog, Cat, Human, Mouse, Rat)에 반응하며 보존제 무첨가 PBS 용액 형태로 제공.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Cat, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HL1598 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Calnexin. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2938178 |
Product Specific Information
- Store as concentrated solution.
- Centrifuge briefly prior to opening vial.
Target Information
Calnexin (also known as IP90, p88, p90) is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). It functions as a molecular chaperone involved in proper protein folding and assembly.
Calnexin associates with MHC class I heavy chains and partial complexes of T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes.
It retains incompletely folded proteins in the ER.
Soluble ER proteins often contain a KDEL sequence for retention, while integral ER proteins like calnexin use positively charged cytosolic residues for ER localization.
Calnexin contains:
- ER luminal domain: 461 amino acids
- Transmembrane segment: 22 amino acids
- Cytoplasmic tail: 89 amino acids
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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