Thermo Fisher Scientific Phospho-PPAR delta (Thr256) Polyclonal Antibody

Applications and Tested Dilution

Species Reactivity

Pig, Rat, Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PPARD (Accession Q03181), corresponding to amino acid residues around phosphorylated Thr256.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Sequential chromatography

Storage Buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage Conditions

-20°C

Shipping Conditions

Wet ice

RRID

AB_2816555

Product Specific Information

This antibody detects endogenous levels of PPARD only when phosphorylated at Thr256.

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and regulate the size and number of peroxisomes in cells.
PPARs mediate various biological processes and may be involved in chronic diseases such as diabetes, obesity, atherosclerosis, and cancer.
The protein acts as a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma, and may function as an integrator of transcription repression and nuclear receptor signaling.
Expression of this gene is elevated in colorectal cancer cells and can be repressed by the tumor suppressor protein APC, related to the APC/beta-catenin signaling pathway.
Knockout studies in mice suggest roles in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.