Thermo Fisher Scientific GSK3B Recombinant Rabbit Monoclonal Antibody (1H9L3)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:5,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

This antibody is predicted to react with non-human primate, mouse, and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generates a ~25 kDa light chain and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal development, and body pattern formation.
It negatively regulates glucose homeostasis and plays roles in inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways.
GSK3B is a key component of the Wnt/beta-catenin signaling pathway, mediating beta-catenin degradation and inhibiting Wnt signaling.
It is also involved in Hedgehog, Notch, and insulin signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.