Thermo Fisher Scientific CD44 Monoclonal Antibody (MEM-85), APC

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular antigen of both cell surface-expressed and soluble forms of CD44 antigen (Phagocyte glycoprotein 1), an 80–95 kDa transmembrane glycoprotein (hyaladherin family) present on most cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes.

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.

CD44 is a receptor for hyaluronic acid (HA) and is involved in:

• Cell-cell interactions
• Cell adhesion and migration
• Lymphocyte activation, recirculation, and homing

CD44 expression may be upregulated in some carcinomas, potentially related to metastatic potential. It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression upon stimulation.

Transcripts for the CD44 gene undergo complex alternative splicing, resulting in many functionally distinct isoforms. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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