Thermo Fisher Scientific CD44 Monoclonal Antibody (MEM-263), APC

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA1-19277)
• FITC (MA1-10228)
• PE (MA1-19781)
• Request custom conjugation available

Product Specific Information

This antibody reacts with the extracellular (N-terminal) domain of standard CD44 (Phagocyte glycoprotein 1), an 80–95 kDa transmembrane glycoprotein (hyaladherin family) present on most cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.). It is negative on platelets and hepatocytes.

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 acts as a receptor for hyaluronic acid (HA) and participates in cell-cell interactions, adhesion, and migration. It plays roles in lymphocyte activation, recirculation, and homing. CD44 expression may increase in certain carcinomas, possibly related to metastatic potential.
It is expressed in hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression in response to stimulation.
Transcripts of the CD44 gene undergo complex alternative splicing, producing diverse isoforms with distinct functions. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be linked to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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