Thermo Fisher Scientific Phospho-Axl (Tyr703) Polyclonal Antibody
Phospho-Axl (Tyr703) 특이적 항체로, 인간·마우스·랫트 시료에서 인산화된 AXL 단백질 검출에 사용됩니다. Western blot, IHC, ICC/IF에 적합하며, 고순도 정제 및 안정한 PBS/glycerol 버퍼로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AXL (Accession P30530), corresponding to amino acid residues around phosphorylated Tyr703 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816989 |
Product Specific Information
This antibody detects endogenous levels of AXL only when phosphorylated at Tyr703.
Target Information
AXL is a receptor tyrosine kinase associated with chronic myelogenous leukemia, colon cancer, and melanoma. It mediates signal transduction from the extracellular matrix into the cytoplasm by binding growth factors such as GAS6, promoting cell proliferation. TAM receptors, including AXL, are also involved in phagocytosis of apoptotic cells. Deficiency in TAM receptors can lead to autoimmune disorders similar to systemic lupus erythematosus. AXL may also function as an entry receptor for filoviruses and serves as a marker for a specific subpopulation of human blood dendritic cells (Siglec 6+/Axl+). Its expression can be upregulated by TLR ligands, and soluble AXL is generated via proteolytic cleavage. Elevated plasma AXL levels may indicate inflammation or cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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