Thermo Fisher Scientific Phospho-MARCKS (Ser170) Polyclonal Antibody
MARCKS 단백질의 Ser170 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 실험에 적합. 고순도 정제 및 안정한 PBS/glycerol buffer로 제공. 연구용으로만 사용 가능.
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- PA5105558
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MARCKS (Accession P29966), corresponding to amino acid residues around phosphorylated Ser170 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816986 |
Product Specific Information
Antibody detects endogenous levels of MARCKS only when phosphorylated at Ser170.
Target Information
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and acts as an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and the plasma membrane, leading to its presence in the cytoplasm. The protein is involved in cell motility, phagocytosis, membrane trafficking, and mitogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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