Thermo Fisher Scientific BCL9L Monoclonal Antibody (3B9C1)
BCL9L 단백질을 인식하는 Mouse monoclonal antibody(클론 3B9C1). Western blot, IHC(P), ELISA에 사용 가능. Human 시료 반응성. Protein G 정제, 1 mg/mL 농도, PBS buffer(0.05% sodium azide 포함). 4°C 단기 보관, -20°C 장기 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B9C1 |
| Immunogen | Purified recombinant fragment of human BCL9L (AA: 606–751) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787274 |
Product Specific Information
MA5-31650 has been tested in indirect ELISA.
Target Information
Bcl9L, a homolog of Bcl9, was initially identified through bioinformatics screening. It is expressed in fetal brain, adult lung, eye, and prostate, as well as in several tumor types including pancreatic and prostate cancers.
Bcl9L interacts with beta-catenin, a target of the Wnt signaling pathway, and is required for enhanced beta-catenin–TCF-mediated transcription in colorectal tumor cells, possibly by translocating beta-catenin to the nucleus.
Studies indicate that Bcl9L expression correlates with high nuclear grade cancer phenotype and ErbB2/HER-2 expression in breast cancers, suggesting activity in other cancer types.
Bcl9L is also critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas, which are associated with tumor invasion, metastasis, and therapy resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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