Thermo Fisher Scientific BIN1 Monoclonal Antibody (3B6A4)
BIN1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, Flow cytometry, ELISA에 사용 가능. Human 및 Mouse 시료에 반응하며, Protein G로 정제된 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B6A4 |
| Immunogen | Purified recombinant fragment of human BIN1 (AA: 189–398) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787275 |
Product Specific Information
MA5-31651 has been tested in indirect ELISA.
Target Information
The BIN1 gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with tumor suppressor features. Isoforms expressed in the central nervous system may be involved in synaptic vesicle endocytosis and interact with dynamin, synaptojanin, endophilin, and clathrin. Muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and can activate a caspase-independent apoptotic process. Mouse studies suggest that this gene plays an important role in cardiac muscle development. Alternative splicing results in ten transcript variants encoding different isoforms, and aberrant splice variants have been observed in tumor cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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